Flash 治療是一種實驗性療法,使用超高劑量率對治療靶區進行通常短於 1 秒的放射治療。
Flash 治療可能是數十年來癌症治療最重要的進展之一。
Flash 治療是一種實驗性療法,使用超高劑量率對治療靶區進行通常短於 1 秒的放射治療。與傳統療法相比,對老鼠的臨床前研究顯示出 Flash 治療在腫瘤控制、降低對於正常組織的毒性和增強免疫優勢等方面具有同等或更佳的表現。
瓦里安的 FlashForward™ Consortium 是由世界各地的機構組成,旨在建立臨床前研究設計、開發技術解決方案,並分享研究試驗計畫,以利協助推動 Flash 治療的科學進展和臨床轉譯。
Consortium 成員
- The Christie/ MCRC
- CHUV Lausanne University Hospital
- The Cincinnati Children’s/University of Cincinnati Medical Center Proton Therapy Center
- Danish Center for Particle Therapy, Aarhus University Hospital
- Guangzhou Concord Cancer Center
- Haukeland University Hospital
- Hefei Ion Medical Center (Ion Medical Center, The First Affiliated Hospital of USTC)
- Her Royal Highness Princess Maha Chaki Sirindhorn Proton Center
- Holland PTC
- Institut Curie
- Mount Sinai
- Montefiore Einstein Cancer Center
- The New York Proton Center
- The Ohio State University
- Amsterdam UMC
- OSF Healthcare Cancer Institute
- Division of Cancer Medicine, Oslo University Hospital
- Paul Scherrer Institute
- Penn Medicine Radiation Oncology
- Proton Therapy Center of Dr. Berezin Medical Institute (MIBS)
- Proton Therapy SG
- Shandong Proton Therapy Center
- South Florida Proton Therapy Institute
- Suranaree University of Technology
- University College London
- University Hospital Zurich and University of Zurich, Department of Radiation Oncology
- University of Alabama at Birmingham
- University of Maryland, Baltimore
- University of Miami
- University of Nebraska Medical Center
- Wuhan Union Hospital Proton Center
全球首次 Flash 臨床試驗
Flash 質子放射治療用於治療症狀性骨轉移的可行性研究(FAST-01)
FAST-01 是首例人體臨床試驗,針對骨轉移在四肢部位並引發疼痛的患者進行治療,同時評估 Flash 放射治療的可行性和安全性。在 Flash 劑量率下,以 250MeV 透射質子束給予單次 8 Gy 的標準緩和劑量分次治療。FAST-01 研究已於辛辛那提兒童醫院醫療中心完成招募患者(計畫主持人:J. Breneman 醫師)。後續試驗 FAST-02 的設計正在進行中。
研究詳情:
- 四肢骨轉移患者
- 該研究現已開放報名
- 本研究使用修改後的 ProBeam 做為 IDE。
- 與辛辛那提兒童/辛辛那提大學醫療中心質子治療中心合作
如需更多資訊,請參閱 Flash 放射治療用於治療症狀性骨轉移的可行性研究。
Trials using Flash radiotherapy for lung cancer and other malignancies are currently being developed. Using Flash treatment for these cancers could deliver higher cancer-killing doses without causing inordinate side effects, which would be a real advance.
Flash therapy has the potential to be practice-changing and drastically improve the experience of cancer care for a new generation of patients. The launch of the first Flash clinical trial, a project that has come to fruition after years of intensive study, is an important milestone in the progress of radiation therapy.
資源
文章
- An Industry/Academic Partnership Yields Fruit: An Ultra-High Dose Rate Beam Monitoring Tool for Flash Trials
- Flash Stance — Updates in Ultrahigh Dose Rate Radiation Therapy
- A Framework for Defining Flash Dose Rate for Pencil Beam Scanning
- Flash therapy: An inside look at this innovative treatment technology
新聞稿
- Varian and the Cincinnati Children's/UC Health Proton Therapy Center Complete Enrollment of FAST-01, First Human Clinical Trial of Flash Therapy for Cancer
- Varian and the Cincinnati Children's/UC Health Proton Therapy Center Announce Initial Patient Treated in the FAST-01 First Human Clinical Trial of Flash Therapy for Cancer